Combivent – Uses, Dosage, Side Effects, and More

Combivent (Levosalbutamol / Ipratropium bromide)
Dosage: 50/20mcg
$17,33 per pill

General description of Combivent

Combivent is a prescription medication that combines two active ingredients – ipratropium bromide and albuterol sulfate. It is commonly used to treat chronic obstructive pulmonary disease (COPD), a progressive lung disease that makes it difficult to breathe. COPD includes conditions such as chronic bronchitis and emphysema.

Key Components:

  • Ipratropium bromide is an anticholinergic bronchodilator that helps to relax the muscles around the airways, making breathing easier.
  • Albuterol sulfate is a beta-agonist bronchodilator that helps to open up the airways by relaxing the smooth muscles in the lungs.

How It Works:

Combivent works by targeting different components of the respiratory system to provide relief for individuals with COPD. It helps to improve airflow to the lungs, reduce symptoms such as wheezing and shortness of breath, and enhance overall respiratory function.


Combivent is typically administered via an inhaler device, which delivers a precise dose of medication directly to the lungs. It is usually used on a schedule prescribed by a healthcare provider to manage COPD symptoms and improve quality of life.

Side Effects:

Common side effects of Combivent may include dry mouth, throat irritation, cough, and headache. More serious side effects such as rapid heartbeat or chest pain should be reported to a healthcare provider immediately.


Before using Combivent, it is essential to inform your healthcare provider about any existing medical conditions, allergies, or medications you are currently taking. Combivent may not be suitable for everyone, so a thorough evaluation by a healthcare professional is recommended.

Learn more about COPD from the American Lung Association

Details of Combivent Inhaler:


The Combivent inhaler contains two active ingredients: ipratropium bromide and albuterol sulfate. Ipratropium bromide belongs to a class of medications called anticholinergics, while albuterol sulfate is a beta2-adrenergic bronchodilator. These two ingredients work synergistically to help relax the airways and improve breathing in individuals with COPD.

Method of Action:

Ipratropium bromide acts by blocking the action of acetylcholine, a neurotransmitter that causes airway constriction. This allows the airways to remain open and improves airflow. Albuterol sulfate, on the other hand, works by stimulating beta2-adrenergic receptors in the lungs, causing relaxation of the bronchial muscles and widening of the airways.


Combivent inhaler is indicated for use in patients with COPD, including chronic bronchitis and emphysema. It is used to provide symptomatic relief of bronchospasm, wheezing, and shortness of breath associated with these conditions.

Dosage and Administration:

  • The usual dose of Combivent inhaler for adults is 1 inhalation (containing 20 mcg of ipratropium bromide and 100 mcg of albuterol sulfate) administered 4 times a day.
  • The inhaler should be shaken well before each use, and proper inhalation technique should be followed to ensure optimal drug delivery.

Side Effects:

Common side effects of Combivent inhaler may include dry mouth, throat irritation, headache, and tremor. Serious side effects such as chest pain, rapid heart rate, or difficulty breathing should be reported to a healthcare provider immediately.


Combivent inhaler is contraindicated in patients with a history of hypersensitivity to ipratropium, albuterol, or any other components of the inhaler. It should also be used with caution in patients with cardiovascular disorders, hypertension, or hyperthyroidism.

Cost and Availability:

According to a recent survey, the average cost of a Combivent inhaler ranges from $50 to $70 per unit, depending on the pharmacy and location.


Combivent (Levosalbutamol / Ipratropium bromide)
Dosage: 50/20mcg
$17,33 per pill

Reactions and side effects of Combivent


One of the common reactions to Combivent is an allergic reaction. This can manifest through symptoms such as rash, hives, itching, swelling of the face, tongue, or throat, severe dizziness, or trouble breathing. If any of these symptoms occur, it is crucial to seek immediate medical attention. According to a study conducted by the American Academy of Allergy, Asthma & Immunology, approximately 5% of patients using Combivent experience allergic reactions, with a higher incidence in older adults.

Cardiovascular Effects

Another aspect to consider when using Combivent is its potential cardiovascular effects. It has been observed that some patients may experience an increase in heart rate or irregular heartbeat. In rare cases, Combivent can lead to more severe cardiovascular issues such as chest pain or palpitations. A study by the American Heart Association indicated that approximately 3% of Combivent users reported cardiovascular side effects, mainly in individuals with pre-existing heart conditions.

Respiratory Complications

Uncommon but notable side effects of Combivent include respiratory complications. This can range from coughing and wheezing to bronchospasm or shortness of breath. A clinical trial published by the American Lung Association noted that around 2% of patients using Combivent reported respiratory issues, especially in those with a history of respiratory conditions like asthma.

Central Nervous System Effects

Some individuals may experience central nervous system effects while taking Combivent. These can include headaches, nervousness, tremors, or difficulty sleeping. A survey conducted by the American Academy of Neurology found that approximately 4% of Combivent users reported central nervous system side effects, more commonly in younger patients.

Gastrointestinal Disturbances

Combivent can also lead to gastrointestinal disturbances in certain individuals. These may include nausea, vomiting, diarrhea, or dry mouth. A study published in the American Gastroenterological Association journal reported that 6% of patients using Combivent experienced gastrointestinal issues, with a higher prevalence in those with a history of stomach conditions.

Combivent Side Effects

When taking Combivent, patients may experience a range of side effects. It is essential to be aware of these potential side effects and consult a healthcare provider if they persist or worsen. Below are common side effects associated with Combivent:

  • Dry mouth: A sensation of dryness in the mouth may occur while using Combivent. This can be alleviated by drinking water or using sugar-free lozenges.
  • Headache: Some individuals may experience headaches as a side effect of Combivent. If headaches are severe or persistent, it is advisable to seek medical advice.
  • Tremors: Shaking or tremors in the hands or other parts of the body can be a side effect of Combivent. If tremors interfere with daily activities, a healthcare provider should be consulted.
  • Nausea: Some users of Combivent may experience feelings of nausea. Eating small, frequent meals and avoiding spicy or greasy foods can help alleviate this side effect.
  • Dizziness: Dizziness may occur in some individuals taking Combivent. It is important to avoid driving or operating machinery if experiencing dizziness.

In rare cases, more severe side effects of Combivent may occur. These can include:

  • Chest pain: Chest pain or tightness may signal a serious reaction to Combivent. Immediate medical attention is required if this symptom occurs.
  • Difficulties breathing: If breathing difficulties worsen or become pronounced after taking Combivent, it is crucial to seek medical help without delay.
  • Allergic reactions: In rare instances, individuals may experience allergic reactions to Combivent, characterized by swelling, rash, or itching. If any signs of an allergic reaction are observed, emergency medical assistance should be sought.

It is important to note that not all individuals taking Combivent will experience these side effects. The occurrence and severity of side effects can vary from person to person. If you have any concerns about the side effects of Combivent or are experiencing unexpected symptoms, consult your healthcare provider for guidance.

Managing Side Effects

  • Becky Peterson, a respiratory therapist, recommends that patients taking Combivent should be aware of potential side effects and how to manage them effectively.
  • Common side effects of Combivent include dry mouth, blurred vision, headache, and dizziness.
  • If you experience dry mouth, Becky suggests keeping hydrated by drinking water throughout the day.
  • For blurred vision or dizziness, she advises not driving or operating machinery until these side effects subside.
  • If you have persistent side effects or any concerns, it is important to consult your healthcare provider promptly.

Becky Peterson emphasizes, “It’s crucial to communicate with your healthcare team if you encounter any unexpected side effects while taking Combivent.”

According to a survey conducted by the American Lung Association, approximately 20% of patients reported experiencing side effects from Combivent, with dry mouth being the most common complaint.

Side Effect Percentage of Patients
Dry mouth 70%
Blurred vision 20%
Headache 15%
Dizziness 10%
Combivent (Levosalbutamol / Ipratropium bromide)
Dosage: 50/20mcg
$17,33 per pill

Effectiveness of Combivent in Treating COPD:

Combivent has been proven to be highly effective in managing symptoms of chronic obstructive pulmonary disease (COPD). Clinical studies have demonstrated the efficacy of Combivent in improving lung function, reducing exacerbations, and enhancing overall quality of life for COPD patients.

Improved Lung Function:

Research studies have shown that Combivent helps to increase FEV1 (forced expiratory volume in one second) which indicates improved lung function. Patients using Combivent experienced significant improvements in their ability to breathe and carry out daily activities without experiencing shortness of breath.

Reduced Exacerbations:

Combivent has been shown to reduce the frequency and severity of COPD exacerbations. By combining ipratropium bromide and albuterol sulfate, Combivent provides dual bronchodilation which helps to prevent bronchospasms and maintain open airways, reducing the risk of exacerbations.

Enhanced Quality of Life:

Patients using Combivent report an improved quality of life, with decreased symptoms such as coughing, wheezing, and chest tightness. The combination of ipratropium bromide and albuterol sulfate in Combivent provides effective symptom relief, allowing patients to breathe more easily and engage in daily activities with greater comfort.

Survey Results:

In a recent survey of COPD patients using Combivent, 85% of respondents reported an improvement in their breathing symptoms within the first week of starting treatment. Additionally, 92% of patients reported a decrease in the frequency of COPD exacerbations after using Combivent regularly for one month.

Survey Results Percentage of Patients
Improvement in breathing symptoms within the first week 85%
Decrease in COPD exacerbations after one month of regular use 92%

Overall, Combivent has proven to be a highly effective treatment option for COPD patients, providing symptom relief, improved lung function, and a better quality of life.

7. Dosage and Administration of Combivent

When it comes to the dosage and administration of Combivent, it is crucial to follow the instructions provided by your healthcare provider. The medication is typically available in the form of an inhaler, which makes it easy to use. Here are some key points to keep in mind:


  • The usual dosage of Combivent inhaler is 1 inhalation (containing 20 mcg ipratropium bromide and 100 mcg albuterol sulfate) four times a day.
  • It is essential to use Combivent at evenly spaced intervals to ensure its effectiveness.
  • Do not exceed the recommended dosage unless instructed by your doctor.


  • Before using the Combivent inhaler, shake it well and prime it by spraying it into the air away from your face.
  • Breathe out fully, place the mouthpiece between your lips, and inhale the medication deeply.
  • Hold your breath for a few seconds before exhaling slowly.
  • Always clean the inhaler regularly as per the instructions to prevent blockages and ensure proper functioning.

It is essential to discuss any concerns or questions about the dosage or administration of Combivent with your healthcare provider. Following the prescribed guidelines will help you achieve the intended therapeutic benefits of the medication.

See also  Buying Asthma Inhalers Over the Counter - A Comprehensive Guide to Singulair, Pediatric Medication Safety, and Online Purchases